Pharmacogical Potential And Bioactivity Of Mangifera indica L.: A Scopus-Based Bibliometric Analysis

Niken Dwi Astuti; Peppy  Octaviani; Rani  Prabandari

doi:10.56359/pharmgen.v4i3.855

Authors

Niken Dwi Astuti Universitas Harapan Bangsa
Peppy Octaviani Universitas Harapan Bangsa
Rani Prabandari Universitas Harapan Bangsa

DOI:

https://doi.org/10.56359/pharmgen.v4i3.855

Keywords:

bibliometric analysis, bioactivity, mangifera indica l, pharmacological potential, scopus database

Abstract

Introduction: Mangifera indica L. (mango) is a tropical plant valued in traditional medicine and rich in bioactive compounds such as mangiferin, quercetin, and catechin, known for antioxidant, anti-inflammatory, antimicrobial, antidiabetic, hepatoprotective, and immunomodulatory activities. Despite increasing research, no comprehensive bibliometric mapping of its pharmacological potential and bioactivity has been conducted.

Objective: To analyze global research trends, influential contributors, and thematic foci on the pharmacological potential and bioactivity of Mangifera indica L. using a Scopus-based bibliometric approach.

Method: Publications from 2015–2024 were retrieved from Scopus using defined Boolean search terms. Only English-language journal articles in the final publication stage were included, resulting in 305 records. Data were analyzed using Microsoft Excel 2021, Bibliometrix/Biblioshiny, and VOSviewer to evaluate performance indicators, thematic evolution, and network visualization of co-authorship, co-citation, and keyword co-occurrence.

Kesimpulan: Annual publications peaked in 2023 (n=50) and 2024 (n=54), showing growing scholarly interest. Industrial Crops and Products was the most influential journal, strongly linked to Molecules and Food Chemistry. CASAS L and MANTELL C were the most productive authors (7 articles each), while Ho Chi Minh City University of Technology led institutional output (47 articles). India was the most prolific country and a central hub for collaborations. Keyword mapping revealed two clusters: phytochemistry and bioactivity, and methodological advances. Research on Mangifera indica L. has expanded significantly in the last decade, bridging pharmacognosy, food science, and nanotechnology. However, gaps remain in translational research and clinical application.

References

Akhavan, P., Ebrahim, N. A., Fetrati, M. A., & Pezeshkan, A. (2016). Major trends in knowledge management research: A bibliometric study. Scientometrics, 107, 1249–1264.

Araújo, A., Carvalho, A. C. P. de L. F. de, & Braga, A. (2007). Journal of Intelligent and Fuzzy Systems.

Ball, R., & Tunger, D. (2006). Bibliometric analysis-a new business area for information professionals in libraries? Support for scientific research by perception and trend analysis. Scientometrics, 66, 561–577.

Batubara, H. S., Jalinus, N., & Rizal, F. (2024). Mapping the Frontier: A Bibliometric Analysis of AI in Tertiary Education. IJLTER. ORG, 23(10), 62–81.

Bucciantini, M., Leri, M., Nardiello, P., Casamenti, F., & Stefani, M. (2021). Olive polyphenols: Antioxidant and anti-inflammatory properties. Antioxidants, 10(7), 1044.

Cao, S., Pang, Y., Wei, Y., Wang, D., Xiong, A., Yang, J., & Zeng, H. (2025). Unveiling the dynamic trends of plant-derived exosome nanovesicles-based theranostics: Through bibliometric and visualized analysis. Frontiers in Medicine, 12, 1553915.

Chaksmithanont, P., Bangsitthideth, K., Arunprasert, K., Patrojanasophon, P., & Pornpitchanarong, C. (2024). Statistical-Based Optimization of Modified Mangifera indica Fruit Starch as Substituent for Pharmaceutical Tableting Excipient. Polymers, 16(18), 2653.

Chandraker, S. K., Ghosh, M. K., Lal, M., & Shukla, R. (2021). A review on plant-mediated synthesis of silver nanoparticles, their characterization and applications. Nano Express, 2(2), 022008.

Chandraker, S. K., Lal, M., Dhruve, P., Yadav, A. K., Singh, R. P., Varma, R. S., & Shukla, R. (2022). Bioengineered and biocompatible silver nanoparticles from Thalictrum foliolosum DC and their biomedical applications. Clean Technologies and Environmental Policy, 24(8), 2479–2494.

Cristani, M., & Micale, N. (2024). Bioactive compounds from medicinal plants as potential adjuvants in the treatment of mild acne vulgaris. Molecules, 29(10), 2394.

Devatha, C., Thalla, A. K., & Katte, S. Y. (2016). Green synthesis of iron nanoparticles using different leaf extracts for treatment of domestic waste water. Journal of Cleaner Production, 139, 1425–1435.

Douaioui, K., & Benmoussa, O. (2024). Insights into industrial efficiency: An empirical study of blockchain technology. Big Data and Cognitive Computing, 8(6), 62.

Elmowafy, M., Shalaby, K., Elkomy, M. H., Alsaidan, O. A., Gomaa, H. A., Abdelgawad, M. A., & Mostafa, E. M. (2023). Polymeric nanoparticles for delivery of natural bioactive agents: Recent advances and challenges. Polymers, 15(5), 1123.

Fahimnia, B., Sarkis, J., & Davarzani, H. (2015). Green supply chain management: A review and bibliometric analysis. International Journal of Production Economics, 162, 101–114.

Gupta, B., Ahmed, K. M., Dhawan, S., & Gupta, R. (2018). Yoga research a scientometric assessment of global publications output during 2007-16. Pharmacognosy Journal, 10(3).

Hou, X., Jiang, X., Zhang, W., & Liu, J. (2025). Bibliometric analysis of nanomaterials in hepatocellular carcinoma treatment: Research trends, knowledge structures, and emerging insights (2000–2024). Discover Oncology, 16(1), 1–23.

Khadka, D., Dhamala, M. K., Li, F., Aryal, P. C., Magar, P. R., Bhatta, S., Thakur, M. S., Basnet, A., Cui, D., & Shi, S. (2021). The use of medicinal plants to prevent COVID-19 in Nepal. Journal of Ethnobiology and Ethnomedicine, 17(1), 26.

Koskinen, J., Isohanni, M., Paajala, H., Jääskeläinen, E., Nieminen, P., Koponen, H., Tienari, P., & Miettunen, J. (2008). How to use bibliometric methods in evaluation of scientific research? An example from Finnish schizophrenia research. Nordic Journal of Psychiatry, 62(2), 136–143.

Krishna, S., Dinesh, K., & Nazeema, P. (2020). Globalizing ayurveda-opportunities and challenges. Int J Health Sci Res, 10(3), 55–68.

Kumar, M., Saurabh, V., Tomar, M., Hasan, M., Changan, S., Sasi, M., Maheshwari, C., Prajapati, U., Singh, S., & Prajapat, R. K. (2021). Mango (Mangifera indica L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities. Antioxidants (Basel, Switzerland), 10(2), 299.

Merigó, J. M., & Yang, J.-B. (2017). A bibliometric analysis of operations research and management science. Omega, 73, 37–48.

Mishra, D., Gunasekaran, A., Papadopoulos, T., & Childe, S. J. (2018). Big Data and supply chain management: A review and bibliometric analysis. Annals of Operations Research, 270, 313–336.

Mitra, S., & Devi, H. (2016). Organic horticulture in India. Horticulturae, 2(4), 17.

Nguyen, T. V., Ho-Le, T. P., & Le, U. V. (2017). International collaboration in scientific research in Vietnam: An analysis of patterns and impact. Scientometrics, 110(2), 1035–1051.

Perianes-Rodriguez, A., Waltman, L., & Van Eck, N. J. (2016). Constructing bibliometric networks: A comparison between full and fractional counting. Journal of Informetrics, 10(4), 1178–1195.

Ramezanzadeh, M., Bahlakeh, G., Sanaei, Z., & Ramezanzadeh, B. (2019). Corrosion inhibition of mild steel in 1 M HCl solution by ethanolic extract of eco-friendly Mangifera indica (mango) leaves: Electrochemical, molecular dynamics, Monte Carlo and ab initio study. Applied Surface Science, 463, 1058–1077.

Shahbaz, M., Akram, A., Raja, N. I., Mukhtar, T., Mehak, A., Fatima, N., Ajmal, M., Ali, K., Mustafa, N., & Abasi, F. (2023). Antifungal activity of green synthesized selenium nanoparticles and their effect on physiological, biochemical, and antioxidant defense system of mango under mango malformation disease. PLoS One, 18(2), e0274679.

Sydnes, L. K. (2018). Health for All in Dhaka: CHEMRAWN helps establish an International Centre for Natural Product Research. Chemistry International, 40(2), 17–19.

Tirado-Kulieva, V., Atoche-Dioses, S., & Hernández-Martínez, E. (2021). Phenolic compounds of mango (Mangifera indica) by-products: Antioxidant and antimicrobial potential, use in disease prevention and food industry, methods of extraction and microencapsulation. Scientia Agropecuaria, 12(2), 283–293.

Ullah, R., Asghar, I., & Griffiths, M. G. (2023). An Integrated Methodology for Bibliometric Analysis: A Case Study of Internet of Things in Healthcare Applications. Sensors, 23(1). https://doi.org/10.3390/s23010067

Ungogo, M. A., Ebiloma, G. U., Ichoron, N., Igoli, J. O., De Koning, H. P., & Balogun, E. O. (2020). A review of the antimalarial, antitrypanosomal, and antileishmanial activities of natural compounds isolated from Nigerian flora. Frontiers in Chemistry, 8, 617448.

Vieira, E. S., & Gomes, J. A. (2009). A comparison of Scopus and Web of Science for a typical university. Scientometrics, 81, 587–600.

Waltman, L., & Van Eck, N. J. (2013). A smart local moving algorithm for large-scale modularity-based community detection. The European Physical Journal B, 86(11), 471.

Yadav, S., Malik, K., Moore, J. M., Kamboj, B. R., Malik, S., Malik, V. K., Arya, S., Singh, K., Mahanta, S., & Bishnoi, D. K. (2024). Valorisation of agri-food waste for bioactive compounds: Recent trends and future sustainable challenges. Molecules, 29(9), 2055.

Yu, D., Xu, Z., & Fujita, H. (2019). Bibliometric analysis on the evolution of applied intelligence. Applied Intelligence, 49(2), 449–462.

Yu, D., Xu, Z., & Pedrycz, W. (2020). Bibliometric analysis of rough sets research. Applied Soft Computing, 94, 106467.

Yu, D., Xu, Z., Pedrycz, W., & Wang, W. (2017). Information sciences 1968–2016: A retrospective analysis with text mining and bibliometric. Information Sciences, 418, 619–634.

Zhang, L., & Ma, L. (2023). Is open science a double-edged sword?: Data sharing and the changing citation pattern of Chinese economics articles. Scientometrics, 128(5), 2803–2818.

Firmansyah, A., Setiawan, H., & Ariyanto, H. (2021). Studi Kasus Implementasi Evidence-Based Nursing: Water Tepid Sponge Bath Untuk Menurunkan Demam Pasien Tifoid. Viva Medika: Jurnal Kesehatan, Kebidanan Dan Keperawatan, 14(2), 174–181.

Setiawan, H., Ariyanto, H., Firdaus, F. A., & Khaerunnisa, R. N. (2021). pendidikan kesehatan pencegahan skabies di pondok pesantren al-arifin. Martabe, 4(1), 110–117.

Theofanidis, D. (2007). Chronic illness in childhood: psychosocial adaptation and nursing support for the child and family. Health Science Jornal, 1(2), 1–9. Retrieved from http://www.hsj.gr/index.files/VOLUME1_2.htm