Overview of Immature Reticulocyte Fraction (IRF) and Red Cell Distribution Width-Coefficient Variation (RDW-CV) in Patients with Hemoglobin Levels Below 8
DOI:
https://doi.org/10.56359/igj.v4i3.631Keywords:
Anemia, IRF, RDW-CVAbstract
Background & Objective: Anemia is a condition in which the number or volume of erythrocytes or red blood cells and hemoglobin (Hb) molecules in the body are reduced. This condition occurs when hemoglobin levels or hematocrit (Ht) values decrease. Anemia can occur due to several factors, such as iron deficiency, vitamin B12 deficiency, folic acid deficiency, genetic factors, chronic diseases, intestinal worms, and bleeding. This study aims to determine the profile of immature reticulocyte fraction (IRF) and red cell distribution width-coefficient variation (RDW-CV) in patients with hemoglobin levels below 8.
Method: This type of research is descriptive research, using purposive sampling with 30 respondents.
Result: The results of this study obtained IRF RDW values -CV of 15 with a percentage of (50%), normal IRF RDW-CV of 10 with a percentage of (33%), normal IRF RDW-CV of 2 with a percentage of (7%), high IRF RDW-CV of 2 with a percentage of (7%), and low IRF RDW-CV of 1 with a percentage of (3%).
Conclusion: The results showed that high IRF and high RDW-CV 15 with a percentage of 50% indicated a more active bone marrow response in producing new red blood cells in response to anemia and the presence of cell size differences known as anisocytosis.
Downloads
References
Adane T, Asrie F, G. Z. (2021). Clinical Utility of Immature Reticulocyte Fraction. J Clin Chem Lab Med, 4(9), 1–5.
Anovadia, D. B., Trivedi, D. D. P., Savjiyani, D. D., & Popat, D. V. C. (2023). Clinical significance of immature reticulocyte fraction (IRF) and reticulocyte maturity indices in differential diagnosis of anemia. International Journal of Clinical and Diagnostic Pathology, 6(1), 16–19. https://doi.org/10.33545/pathol.2023.v6.i1a.505
Chung-Che Chang, MD, PhD, Lawrence Kass, M. (1997). Clinical Significance of Immature Reticulocyte Fraction Determined by Automated Reticulocyte Counting. American Journal of Clinical Pathology. https://academic.oup.com/ajcp/article-abstract/108/1/69/1757187?redirectedFrom=fulltext&login=false
dr. Dian Sukma Hanggara, SpPK, M. B. (2019). Memahami RDW-CV dan RDW-SD. Patologi Klinik.
Eva ayu Maharani, dewi yayuningsih. (2023). Hematologi: Teknologi Laboratorium Medik (Edisi 1). Buku Kedokteran EGC.
Hanggara, D. S. (2019). memahami rdw-cv rdw-sd. Patologi Klinik. https://doi.org/https://patologiklinik.com/2019/12/21/memahami-rdw-cv-dan-rdw-sd/
Kemenkes, R. (2018). Pedoman Penatalaksanaan Pemberian Tablet Tambah Darah. Kemenkes RI, 46. https://promkes.kemkes.go.id/download/fpck/files51888Buku Tablet Tambah darah 100415.pdf
Purnamasari, L. (2024). Reticulocyte Hemoglobin Equivalent (Ret-He) sebagai Parameter Defisiensi Besi pada Bayi dan Anak. Cermin Dunia Kedokteran, 51(4), 221–225. https://doi.org/10.55175/cdk.v51i4.638
Putra, B. F. K., & U. Y. Bintoro. (2019). Red cell Distribution Width sebagai Prediktor Penyakit Kardiovaskuler. Cdk-280, 46(11), 692–696.
Roes, B. A., Prihatni, D., & Tristina, N. (2024). Perbedaan Parameter Eritrosit Dan Retikulosit Pada Pasien Talasemia Beta Minor Dan Anemia Defisiensi Besi Ringan. 4(1), 47–56.
WHO. (2018). Anemia among adolescent and young adult women in Latin America and the Caribbean: A cause for concern. Pan America Heslth Organizatuon, 1–12. http://www.paho.org/hq/dmdocuments/2010/AnemiaEngWEB.pdf
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Nurhayati, Bekti Mastiadji

This work is licensed under a Creative Commons Attribution 4.0 International License.