Efficacy of Guava Leaf Decoction in Lowering Blood Glucose in Diabetes Mellitus: A Systematic Review

Ghina Nurjihan Naurah; Sophia Oktaviani; Dela Gita  Rosalina; Purnama Gandara; Henri  Setiawan; Endrian Mulyadi Justisiya  Waluyo

doi:10.56359/gj.v6i1.532

Authors

Ghina Nurjihan Naurah STIKes Muhammadiyah Ciamis
Sophia Oktaviani STIKes Muhammadiyah Ciamis
Dela Gita Rosalina STIKes Muhammadiyah Ciamis
Purnama Gandara STIKes Muhammadiyah Ciamis
Henri Setiawan STIKes Muhammadiyah Ciamis
Endrian Mulyadi Justisiya Waluyo STIKes Muhammadiyah Ciamis

DOI:

https://doi.org/10.56359/gj.v6i1.532

Keywords:

blood glucose, diabetes mellitus, guava leaf, herbal medicine

Abstract

Introduction: Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels due to insulin resistance or insufficient insulin secretion. The rising global prevalence of DM has led to increased interest in alternative therapies, including herbal remedies such as guava leaf decoction, which is believed to possess hypoglycemic properties.

Objective: This systematic review aims to evaluate the efficacy of guava leaf decoction in reducing blood glucose levels in patients with diabetes mellitus.

Methods: A comprehensive literature search was conducted across four databases—PubMed, ProQuest, Garuda, and JSTOR—for studies published between 2020 and 2024. Inclusion criteria were studies involving diabetic patients receiving guava leaf decoction as an intervention, with outcomes measured in terms of blood glucose levels using glucometers. The selection and quality appraisal of studies were independently performed by two to three reviewers, following the PRISMA guidelines. The CASP checklist was used for methodological quality assessment. Extracted data included study authors, intervention details, facilitators, setting, session frequency, duration, and delivery method.

Results: Eight eligible studies comprising a total of 229 participants were included. The findings consistently demonstrated that guava leaf decoction significantly reduced blood glucose levels. Effective regimens included twice-daily administration for 7 days or once daily (250 ml) for 14 days. Benefits were observed in both diabetic and obese individuals.

Conclusion: Guava leaf decoction shows potential as a complementary therapy in the management of diabetes mellitus by naturally lowering blood glucose levels. Further clinical trials are recommended to confirm its efficacy and safety.

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References

Aizah, S., Risnasari, N., & Listyawati, N. (2022). Efektivitas penggunaan rebusan tumbukan daun jambu biji untuk menurunkan frekuensi diare pada anak. Jurnal EDUNursing, 6(1).

Amin, A. N., Nur Intang, I., Alfira, N., & Nurlaela Amin, A. (2024). Effect of guajava (Psidium) leaves decoction on changes in blood glucose levels of people with diabetes mellitus. Internasional Conference Optimal.

Antoni, A., & Harahap, Y. W. (2019). Efektivitas pencucian luka menggunakan daun jambu biji terhadap tingkat malodor klien luka kaki diabetik. Riset Informasi Kesehatan, 8(2). https://doi.org/10.30644/rik.v8i2.251

Baidhowy, A. S., Armiyati, Y., & Imandarri, J. (2022). Penerapan pencucian luka menggunakan air rebusan daun jambu biji terhadap tingkat malodor pasien luka kaki diabetik. Holistic Nursing Care Approach, 2(1), 16. https://doi.org/10.26714/hnca.v2i1.8758

Buheli, K., Poltekkes, R., & Gorontalo, K. (2021). Pemberian air rebusan daun jambu biji terhadap kadar glukosa darah penderita diabetes melitus. Jambura Health and Sport Journal, 3(1).

Chu, S., et al. (2022). Aqueous extract of guava (Psidium guajava L.) leaf ameliorates hyperglycemia by promoting hepatic glycogen synthesis and modulating gut microbiota. Frontiers in Pharmacology, 13. https://doi.org/10.3389/fphar.2022.907702

Dwitiyanti. (2015). Daun jambu biji (Psidium guajava L.) sebagai antikanker payudara. Pharmaceutical Sciences and Research. https://doi.org/10.7454/psr.v2i2.3323

Faidhil. (2024). Penerapan air rebusan daun jambu biji dalam menurunkan kadar glukosa darah pada penderita diabetes melitus tipe II di Desa Reukih Dayah Kabupaten Aceh Besar. Akademi Keperawatan Kesdam Iskandar Muda Banda Aceh.

Fithriana, D., Putradana, A., & Tinggi Ilmu Kesehatan Mataram. (2021). Pengaruh pemberian air rebusan daun jambu biji (Psidium guajava leaf) terhadap perubahan kadar glukosa darah penderita DM tipe II dengan obesitas di wilayah kerja Puskesmas Jatibaru Kota Bima. Jurnal Ilmu Sosial dan Pendidikan. http://ejournal.mandalanursa.org/index.php/JISIP/index

Hani, U. (2018). Pengaruh pemberian air rebusan daun jambu biji terhadap kadar glukosa darah pada penderita diabetes melitus tipe II di wilayah kerja Puskesmas Pekkabata Kabupaten Polewali Mandar. Bina Generasi: Jurnal Kesehatan, 9(2). https://doi.org/10.35907/jksbg.v9i2.40

Hidayati, R., Cumayunaro, A., & Ridha Hidayati, K. (2020). Pengaruh pemberian air rebusan daun jambu biji terhadap kadar glukosa darah pada penderita diabetes melitus tipe 2. Journal of Scientech Research and Development, 2(1). http://idm.or.id/JSCR

Hoerunisa, R., Setiawan, H., Purwati, A. E., & Hidayat, N. (2023). Pengaruh senam kaki diabetik terhadap penurunan risiko ulkus diabetik pada pasien diabetes melitus tipe II. INDOGENIUS, 2(2). https://doi.org/10.56359/igj.v2i2.227

Ilahi, R. R. (2021). Pengaruh konsentrasi perasan daun jambu biji (Psidium guajava) terhadap sifat fisik masker anti jerawat. Politeknik Harapan Bersama.

Jannah, M., Rahmah, M., Naufal, M., Oktavia Winda, N., & Rakhman Hakim, A. (2024). Literatur review: Efektivitas daun jambu biji (Psidium guajava L.) sebagai obat tradisional. Innovative: Journal of Social Science Research. https://doi.org/10.31004/innovative.v4i4.13083

Jayasudha, P., Chitra, W., & Nirmala, T. (2017). Effect of guava leaf tea on blood sugar level among clients with type II diabetes mellitus at a selected community, Coimbatore. International Journal of Applied Research, 3(11), 218–220.

Manikandan, R., Anand, A. V., Kumar, S., & Pushpa. (2016). Phytochemical and in vitro antidiabetic activity of Psidium guajava leaves. Pharmacognosy Journal, 8(4). https://doi.org/10.5530/pj.2016.4.13

Nugroho, Y. W., Handono, N. P., & GSH. (2022). Efektivitas pemberian rebusan daun jambu biji (Psidium guajava) terhadap penurunan kadar gula darah pada pasien diabetes melitus. Jurnal Keperawatan GSH, 11(2).

Nurayati, L., & Adriani, M. (2017). Hubungan aktivitas fisik dengan kadar gula darah puasa penderita diabetes melitus tipe 2. Amerta Nutrition, 1(2), 23–33. https://doi.org/10.2473/amnt.v1i2.2017.80-87

Permatasari, W., Firmansyah, A., Hidayat, N., Purwati, A. E., Supriadi, D., & Setiawan, H. (2023). Studi kasus status nutrisi pada penderita diabetes melitus. INDOGENIUS, 2(2). https://doi.org/10.56359/igj.v2i2.249

Pramasari, N., Endarti, D., & Widayanti, A. W. (2022). Cost of illness diabetes melitus tipe 2: Narrative review. Jurnal Farmasi Sains dan Praktis, 37–47. https://doi.org/10.31603/pharmacy.v8i1.5958

Priya, K., & Priya, M. (2021). Effectiveness of guava leaf tea in reducing postprandial blood glucose among type-2 diabetic clients. International Journal of Midwifery and Nursing Practice, 4(2), 40–42. http://www.nursingpractice.net

Putri, R. N., Hidayat, N., Supriadi, D., & Setiawan, H. (2023). Perawatan luka modern pada pasien ulkus diabetikum: Sebuah studi kasus intervensi keperawatan. INDOGENIUS, 2(2). https://doi.org/10.56359/igj.v2i2.250

Setiawan, H., Nantia Khaerunnisa, R., Ariyanto, H., Fitriani, A., Firdaus, F. A., & Nugraha, D. (2021). Yoga meningkatkan kualitas hidup pada pasien kanker: Literature review. Journal of Holistic Nursing Science, 8(1). https://doi.org/10.31603/nursing.v8i1.3848

Setiawan, H., Suhanda, S., & Sopatilah, E. (2018). Hubungan tingkat pengetahuan dengan kecemasan penderita diabetes mellitus.

Solihah, R., Purwati, A. E., Setiawan, H., Setiawan, D., & Heryani, H. (2023). Pemeriksaan kadar gula darah dan tekanan darah: Pengabdian masyarakat dosen di wilayah Desa Cikoneng Kabupaten Ciamis. Kolaborasi: Jurnal Pengabdian Masyarakat, 3(6), 353–358.

Tella, T., Masola, B., & Mukaratirwa, S. (2022). Anti-diabetic potential of Psidium guajava leaf in streptozotocin induced diabetic rats. Phytomedicine Plus, 2(2). https://doi.org/10.1016/j.phyplu.2022.100254

Widiastuti, T. C., Fitriati, L., Rahmawati, N., Kumalasari, S., & Putri, F. A. (2023). Uji aktivitas antibakteri kombinasi ekstrak etanol daun jambu biji dan daun mangga arumanis terhadap S. aureus. Jurnal Natural, 16(2). https://doi.org/10.24815/jn.v16i2.5017

Williams, R., et al. (2020). Global and regional estimates and projections of diabetes-related health expenditure: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Research and Clinical Practice, 162. https://doi.org/10.1016/j.diabres.2020.108072

Zahra, W. S., & Assyaidah, S. N. (2025). Perbedaan efektivitas pemberian air rebusan daun binahong dan daun jambu biji merah terhadap penyembuhan luka perineum di UPT Puskesmas Baros. https://doi.org/10.31004/jn.v9i1.31721