Analysis of the Use of the SOFA Score in Predicting Mortality among Critically III Patients
DOI:
https://doi.org/10.56359/gj.v7i1.996Keywords:
ICU, mortality, sepsis shock, SOFA scoreAbstract
Introduction: Sepsis is one of the main causes of morbidity and mortality in critical patients in the Intensive Care Unit (ICU). Delays in identifying organ dysfunction are an important factor that increases the risk of death. The Sequential Organ Failure Assessment (SOFA) Score is an assessment tool that is widely used to measure the extent of organ damage and predict mortality in sepsis patients.
Objective: To know the output results of sepsis and sepsis shock patients and which indicators of the SOFA Score affect the patient's output.
Methods: Quantitative research with a retrospective cohort design with a total population of 102 patients with a sample of 53 patients assisted by scoring assessment using the MDCalc application.
Results: overall output experienced mortality with the indicators that affected the SOFA Score score, namely; MAP, FiO2, Ventilator Use, Billirubin, and GCS. Other indicators that affect output include; RR, Glucose, and Leukocytes.
Conclusion: This study confirms that SOFA Score can be used as an effective prediction tool to assess the prognosis of sepsis patients, as well as sepsis shock so that it can assist health workers in clinical decision-making and therapy planning more appropriately.
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Baihaqi, F. A., Delarosa, D. O., & Ramadhan, R. (2022). Rasio Laktat/Albumin sebagai Prediktor Mortalitas pada Pasien dengan Sepsis dan Syok Sepsis: Studi Meta-Analisis. Jurnal Penyakit Dalam Indonesia, 9(3), 146. https://doi.org/10.7454/jpdi.v9i3.718
Bi, H., Liu, X., Chen, C., Chen, L., Liu, X., Zhong, J., & Tang, Y. (2023). The PaO 2 / FiO 2 is independently associated with 28 ‑ day mortality in patients with sepsis : a retrospective analysis from MIMIC ‑ IV database. 1–8. https://doi.org/10.1186/s12890-023-02491-8
Dharma, B. D. A., Mulyantari, N. K., & Prabawa, I. P. Y. (2020). Analisis korelasi kadar serum prokalsitonin dengan jumlah leukosit pada penderita dengan kecurigaan sepsis di RSUP Sanglah, Bali, Indonesia. Intisari Sains Medis, 11(1), 179–182. https://doi.org/10.15562/ism.v11i1.525
Djupsjö, C., Kuhl, J., Andersson, T., Lundbäck, M., Holzmann, M. J., & Nyström, T. (2022). Admission glucose as a prognostic marker for all ‑ cause mortality and cardiovascular disease. Cardiovascular Diabetology, 1–11. https://doi.org/10.1186/s12933-022-01699-y
Do, S. N., Dao, C. X., Nguyen, T. A., Nguyen, M. H., Pham, D. T., Nguyen, N. T., Huynh, D. Q., Hoang, Q. T. A., Bui, C. Van, Vu, T. D., Bui, H. N., Nguyen, H. T., Hoang, H. B., Le, T. T. P., Nguyen, L. T. B., Duong, P. T., Nguyen, T. D., Le, V. H., Pham, G. T. T., … Luong, C. Q. (2023). Sequential Organ Failure Assessment (SOFA) Score for predicting mortality in patients with sepsis in Vietnamese intensive care units: a multicentre, cross-sectional study. BMJ Open, 13(3). https://doi.org/10.1136/bmjopen-2022-064870
Febriyanti, P., Herman, A., & Thalib, S. (n.d.). Effect of Non-Rebreathing Mask Oxygenation and 30-Degree Head- Up Positioning on Consciousness and Hemodynamics in Pulmonary Tuberculosis Patients : A Case Study. 06(02), 297–304.
Guo, M., He, W., Mao, X., Luo, Y., & Zeng, M. (2023). Association between ICU admission ( neutrophil + monocyte )/ lymphocyte ratio and 30-day mortality in patients with sepsis : a retrospective cohort study. 1–7.
Iskandar, A., & Siska, F. (2020). Analisis Hubungan Sequential Organ Failure Assessment (Sofa) Score Dengan Mortalitas Pasien Sepsis. Jurnal Kesehatan Andalas, 9(2), 168. https://doi.org/10.25077/jka.v9i2.1221
Kokeguchi, H., Toida, C., Tsunoyama, T., Iwashita, M., & Miyake, Y. (2025). Reverse shock index multiplied by Glasgow Coma Scale score as a predictor of urgent trauma care and mortality in isolated severe traumatic brain injury : a 10-year nationwide validation study.
Liu, Y., Sun, W., Guo, Y., Chen, L., Zhang, L., Zhao, S., Long, D., & Yu, L. (2020). Association between platelet parameters and mortality in coronavirus disease 2019 : Retrospective cohort study. 7104, 1–7. https://doi.org/10.1080/09537104.2020.1754383
Mahardika, I. K. D., Yuliani, E., & Nela, A. S. (n.d.). Shift Work as a Predictor of Fatigue Levels Among Inpatient Nurses : A Cross-Sectional Analysis. 06(02), 442–448.
Moreno, R., Rhodes, A., Piquilloud, L., Hernandez, G., Takala, J., Gershengorn, H. B., Tavares, M., Coopersmith, C. M., Myatra, S. N., Singer, M., Rezende, E., Prescott, H. C., Soares, M., Timsit, J. F., de Lange, D. W., Jung, C., De Waele, J. J., Martin, G. S., Summers, C., … Vincent, J. L. (2023). The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update? Critical Care, 27(1), 1–5. https://doi.org/10.1186/s13054-022-04290-9
Ning, Y. Le, Li, W. J., Lu, X., Zhang, Y., Zhang, J. W., & Zhou, J. H. (2024). Association between heart rate and mortality in patients with septic shock : an analysis revealed by time series data. BMC Infectious Diseases. https://doi.org/10.1186/s12879-024-10004-z
Palupi, R., Yuliani, E., & Patria, A. (n.d.). The Relationship between Nursing Service Quality and Patient Satisfaction among Patients Covered by Indonesia ’ s National Health Insurance Scheme. 06(02), 479–485.
Quintairos, A., Pilcher, D., & Salluh, J. I. F. (2023). ICU scoring systems. Intensive Care Medicine, 49(2), 223–225. https://doi.org/10.1007/s00134-022-06914-8
Sari, E. K., Hayati, Y. S., & Rokhmawati, N. L. (2021). Hubungan Skor Sofa Dengan Mortalitas Pada Pasien Sakit Kritis. Majalah Kesehatan, 8(3), 149–155. https://doi.org/10.21776/ub.majalahkesehatan.2021.008.03.4
Sasmita, B. R., Xie, S., Xie, L., Chen, J., Shen, J., Li, X., & Liu, G. (2025). Prognostic value of admission respiratory rate in patients with acute myocardial infarction. BMC Cardiovascular Disorders, 1–11. https://doi.org/10.1186/s12872-025-04729-1
Schuurmans, J., Rossem, B. T. B. Van, Rellum, S. R., Tol, J. T. M., Kurucz, V. C., Mourik, N. Van, Ven, W. H. Van Der, Veelo, D. P., Schenk, J., & Vlaar, A. P. J. (2024). Hypotension during intensive care stay and mortality and morbidity : a systematic review and meta ‑ analysis. Intensive Care Medicine, 50(4), 516–525. https://doi.org/10.1007/s00134-023-07304-4
Study, O. (2025). Association between serum direct bilirubin and 90-day mortality in patients with ARDS. 26(January).
Thakur, R., Naga Rohith, V., & Arora, J. K. (2023). Mean SOFA Score in Comparison With APACHE II Score in Predicting Mortality in Surgical Patients With Sepsis. Cureus, 15(3), 4–11. https://doi.org/10.7759/cureus.36653
Thalib, A. H. S., & Isa, K. H. (n.d.). Implementation of Cardiopulmonary Resuscitation in Patients with Cardiac Arrest. 06(01), 176–181.
van der Poll, T., Shankar-Hari, M., & Wiersinga, W. J. (2021). The immunology of sepsis. Immunity, 54(11), 2450–2464. https://doi.org/10.1016/j.immuni.2021.10.012
Verschoor, C. P., Theou, O., Ma, J., Montgomery, P., Mossey, S., Nangia, P., Saskin, R., & Savage, D. W. (2024). Age- and sex-specific associations of frailty with mortality and healthcare utilization in community-dwelling adults from Ontario , Canada. 1–10.
Wang, D., Zhao, J., Xi, X., Zheng, Y., & Li, W. (2024). Attributable mortality of acute kidney injury among critically ill patients with sepsis : a multicenter , retrospective cohort study. 1–10.
Wang, R., & Dai, H. (2022). Association of platelet count with all- cause mortality from acute respiratory distress syndrome : A cohort study. March, 1–7. https://doi.org/10.1002/jcla.24378
Wang, X., Guo, Z., Chai, Y., Wang, Z., Liao, H., Wang, Z., & Wang, Z. (2023). Application Prospect of the SOFA Score and Related Modification Research Progress in Sepsis. Journal of Clinical Medicine, 12(10). https://doi.org/10.3390/jcm12103493
World Health Organisation. (2020). Global report on the epidemiology and burden of sepsis: current evidence, identifying gaps and future directions. In World Health Organization. http://apps.who.int/bookorders.%0Ahttp://apps.who.int/bookorders.%0Ahttp://apps.who.int/bookorders.%0Ahttps://apps.who.int/iris/bitstream/handle/10665/334216/9789240010789-eng.pdf
Yang, Z., Lv, X., & Yan, J. (2021). Serum Total Bilirubin Level Is Associated With Hospital Mortality Rate in Adult Critically Ill Patients : A Retrospective Study. 8(October), 1–6. https://doi.org/10.3389/fmed.2021.697027
Zhang, K., Shi, Y., Han, Y., Cai, T. Y., Gu, F. M., & Gu, Z. X. (2024). J-Shaped Association Between Respiratory Rate and In-Hospital Mortality in Acute Myocardial Infarction Patients Complicated by Congestive Heart Failure in Intensive Care Unit. 218, 1–11. https://doi.org/10.1177/15593258241303040
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