Effectiveness of the Paleo Diet on Weight-Loss among Individuals with Obesity: A Systematic Literature Review
DOI:
https://doi.org/10.56359/gj.v7i1.873Keywords:
obesity, paleo diet, weight-lossAbstract
Introduction: Obesity has become a significant global public health issue. A variety of intervention strategies have been implemented, encompassing dietary modifications, physical activity, pharmacological treatments, and surgical procedures. Among these, the Paleolithic (Paleo) diet modeled after the presumed dietary patterns of humans during the Paleolithic era has attracted increasing scholarly attention as a potential nutritional approach for obesity management.
Objective: This study aims to systematically review and evaluate the effectiveness of the Paleolithic (Paleo) diet in reducing body weight among individuals with obesity. Through an analysis of existing research, this review seeks to identify the benefits, limitations, and long-term sustainability of the Paleo diet as a weight management strategy.
Method: This study aims to systematically review and evaluate the effectiveness of the Paleolithic (Paleo) diet in reducing body weight among individuals with obesity. Through an analysis of existing research, this review seeks to identify the benefits, limitations, and long-term sustainability of the Paleo diet as a weight management strategy.
Results: A total of 880 participants were included across the seven reviewed studies. The findings revealed that the Paleo diet was effective in promoting weight loss among individuals with obesity. Participants who adhered to the Paleo diet for eight weeks experienced an average reduction of 5.3 kilograms in body weight.
Conclusion: The Paleolithic diet (PD) is effective in reducing body weight, fat mass, and cardiometabolic risk factors compared with conventional diets, particularly in the short term. However, low adherence poses a major challenge, leading to diminished differences in benefits over the long term. Compared with the Mediterranean diet and intermittent fasting, adherence to PD is lower, and thus its long-term effectiveness requires further investigation.
Downloads
References
Brzuszkiewicz, K., Rudziński, G., Pożarowska, K., & Grunwald, A. (2022). Diet and physical activity in the treatment of obesity - current knowledge. Journal of Education, Health and Sport, 12(12). https://doi.org/10.12775/jehs.2022.12.12.028
Buckinx, F., Landi, F., Cesari, M., Fielding, R. A., Visser, M., Engelke, K., Maggi, S., Dennison, E., Al-Daghri, N. M., Allepaerts, S., Bauer, J., Bautmans, I., Brandi, M. L., Bruyère, O., Cederholm, T., Cerreta, F., Cherubini, A., Cooper, C., Cruz-Jentoft, A., … Kanis, J. A. (2018). Pitfalls in the measurement of muscle mass: a need for a reference standard. Journal of Cachexia, Sarcopenia and Muscle, 9(2). https://doi.org/10.1002/jcsm.12268
Buckley, H. R., & Buikstra, J. E. (2019). Stone Agers in the Fast Lane? How Bioarchaeologists Can Address the Paleo Diet Myth. In Bioarchaeology and Social Theory. https://doi.org/10.1007/978-3-319-93012-1_7
Carreira, D., Robison, J. W., Robison, S., & Fitch, A. (2022). Obesity Treatment in Orthopaedic Surgery. In Journal of the American Academy of Orthopaedic Surgeons (Vol. 30, Issue 24, pp. E1563–E1570). Lippincott Williams and Wilkins. https://doi.org/10.5435/JAAOS-D-21-01083
Cherif, B. T., & Hadjedj, B. (2024). Exploring the Impact of Obesity on Self-Confidence and Body Image in Obese Individuals Exploring the Impact of Obesity on Self-Confi dence and. The Journal of El-Ryssala for Studies and Research in Humanities, 09, 227–243.
Christopher, P. (2016). Cutting through the Paleo hype: The evidence for the Palaeolithic diet. Australian Family Physician, 45(1).
Cruwys, T., Norwood, R., Chachay, V. S., Ntontis, E., & Sheffield, J. (2020). “An Important Part of Who I am”: The Predictors of Dietary Adherence among Weight-Loss, Vegetarian, Vegan, Paleo, and Gluten-Free Dietary Groups. Nutrients, 12(4). https://doi.org/10.3390/nu12040970
De Menezes, E. V. A., Sampaio, H. A. D. C., Carioca, A. A. F., Parente, N. A., Brito, F. O., Moreira, T. M. M., De Souza, A. C. C., & Arruda, S. P. M. H. (2019). Influence of Paleolithic diet on anthropometric markers in chronic diseases: Systematic review and meta-analysis. In Nutrition Journal (Vol. 18, Issue 1). https://doi.org/10.1186/s12937-019-0457-z
Destra, E., Anggraeni, N., Firmansyah, Y., & Santoso, A. H. (2023). Waist to hip ratio in Cardiovascular Disease Risk : A Review of the Literature. MAHESA : Malahayati Health Student Journal, 3(6). https://doi.org/10.33024/mahesa.v3i6.10595
Frączek, B., Pięta, A., Burda, A., Mazur-Kurach, P., & Tyrała, F. (2021). Paleolithic diet—effect on the health status and performance of athletes? In Nutrients (Vol. 13, Issue 3). https://doi.org/10.3390/nu13031019
Ghaedi, E., Mohammadi, M., Mohammadi, H., Ramezani-Jolfaie, N., Malekzadeh, J., Hosseinzadeh, M., & Salehi-Abargouei, A. (2019). Effects of a Paleolithic Diet on Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. In Advances in Nutrition (Vol. 10, Issue 4). https://doi.org/10.1093/advances/nmz007
Herrero, P., Rodríguez, M. Á., Ras, M. R., del Pino, A., Arola, L., & Canela, N. (2019). Metabolomics analyses to investigate the role of diet and physical training. In Methods in Molecular Biology (Vol. 1978). https://doi.org/10.1007/978-1-4939-9236-2_25
Jospe, M. R., Roy, M., Brown, R. C., Haszard, J. J., Meredith-Jones, K., Fangupo, L. J., Osborne, H., Fleming, E. A., & Taylor, R. W. (2020). Intermittent fasting, Paleolithic, or Mediterranean diets in the real world: Exploratory secondary analyses of a weight-loss trial that included choice of diet and exercise. American Journal of Clinical Nutrition, 111(3). https://doi.org/10.1093/ajcn/nqz330
Karlsen, M. C., Livingston, K. A., Agoulnik, D., Miki, A., Lichtenstein, A. H., Gilhooly, C. H., Folta, S. C., Economos, C. D., & McKeown, N. M. (2021). Part 2: Theoretical intakes of modern-day paleo diets: Comparison with dietary reference intakes and MyPlate meal plans. Nutrition Today, 56(4). https://doi.org/10.1097/NT.0000000000000490
Leidy, H. J., Clifton, P. M., Astrup, A., Wycherley, T. P., Westerterp-Plantenga, M. S., Luscombe-Marsh, N. D., Woods, S. C., & Mattes, R. D. (2015). The role of protein in weight loss and maintenance. In American Journal of Clinical Nutrition (Vol. 101, Issue 6). https://doi.org/10.3945/ajcn.114.084038
Manheimer, E. W., Van Zuuren, E. J., Fedorowicz, Z., & Pijl, H. (2015). Paleolithic nutrition for metabolic syndrome: Systematic review and meta-analysis. American Journal of Clinical Nutrition, 102(4). https://doi.org/10.3945/ajcn.115.113613
Markofski, M. M., Jennings, K., Dolan, C., Davies, N. A., LaVoy, E. C., Ryan, E. J., & Carrillo, A. E. (2021). Single-Arm 8-Week Ad Libitum Self-Prepared Paleo Diet Reduces Cardiometabolic Disease Risk Factors in Overweight Adults. American Journal of Lifestyle Medicine, 15(6). https://doi.org/10.1177/1559827619866157
Mellberg, C., Sandberg, S., Ryberg, M., Eriksson, M., Brage, S., Larsson, C., Olsson, T., & Lindahl, B. (2014). Long-term effects of a Palaeolithic-type diet in obese postmenopausal women: A 2-year randomized trial. European Journal of Clinical Nutrition, 68(3). https://doi.org/10.1038/ejcn.2013.290
Messina, C., Albano, D., Gitto, S., Tofanelli, L., Bazzocchi, A., Ulivieri, F. M., Guglielmi, G., & Sconfienza, L. M. (2020). Body composition with dual energy X-ray absorptiometry: From basics to new tools. In Quantitative Imaging in Medicine and Surgery (Vol. 10, Issue 8). https://doi.org/10.21037/QIMS.2020.03.02
Moreira, O. C., Oliveira, C. E. P. de, & De Paz, J. A. (2018). Dual energy X-ray absorptiometry (DXA) reliability and intraobserver reproducibility for segmental body composition measuring. Nutrición Hospitalaria. https://doi.org/10.20960/nh.1295
Muscogiuri, G., Verde, L., Sulu, C., Katsiki, N., Hassapidou, M., Frias-Toral, E., Cucalón, G., Pazderska, A., Yumuk, V. D., Colao, A., & Barrea, L. (2022). Mediterranean Diet and Obesity-related Disorders: What is the Evidence? In Current Obesity Reports (Vol. 11, Issue 4). https://doi.org/10.1007/s13679-022-00481-1
Nederhof, E. (2017). Feasibility of a Web-Based Cross-Over Paleolithic Diet Intervention in the General Population. Journal of Evolution and Health, 2(2). https://doi.org/10.15310/2334-3591.1064
Neeland, I. J., Poirier, P., & Després, J. P. (2018). Cardiovascular and Metabolic Heterogeneity of Obesity: Clinical Challenges and Implications for Management. Circulation, 137(13). https://doi.org/10.1161/CIRCULATIONAHA.117.029617
Otten, J., Ryberg, M., Mellberg, C., Andersson, T., Chorell, E., Lindahl, B., Larsson, C., Holst, J. J., & Olsson, T. (2019). Postprandial levels of GLP-1, GIP and glucagon after 2 years of weight loss with a Paleolithic diet: A randomised controlled trial in healthy obese women. European Journal of Endocrinology, 180(6). https://doi.org/10.1530/EJE-19-0082
Pięta, A., Frączek, B., Wiecek, M., & Mazur-Kurach, P. (2023). Impact of Paleo Diet on Body Composition, Carbohydrate and Fat Metabolism of Professional Handball Players. Nutrients, 15(19). https://doi.org/10.3390/nu15194155
Sampaio, H. A. de C., Carioca, A. A. F., Parente, N. de A., & Brito, F. O. (2020). The effects of the paleolithic diet on obesity anthropometric measurements. Revista Brasileira de Cineantropometria e Desempenho Humano, 22. https://doi.org/10.1590/1980-0037.2020v22e69957
Sohouli, M. H., Fatahi, S., Lari, A., Lotfi, M., Seifishahpar, M., Găman, M. A., Rahideh, S. T., AlBatati, S. K., AlHossan, A. M., Alkhalifa, S. A., Alomar, S. A., & Abu-Zaid, A. (2022). The effect of paleolithic diet on glucose metabolism and lipid profile among patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trials. In Critical Reviews in Food Science and Nutrition (Vol. 62, Issue 17). https://doi.org/10.1080/10408398.2021.1876625
Tay, J., Luscombe-Marsh, N. D., Thompson, C. H., Noakes, M., Buckley, J. D., Wittert, G. A., Yancy, W. S., & Brinkworth, G. D. (2015). Comparison of low- and high-carbohydrate diets for type 2 diabetes management: A randomized trial. American Journal of Clinical Nutrition, 102(4). https://doi.org/10.3945/ajcn.115.112581
WA, WaruniS. R., TS, H. P., & M, N. W. (2020). A comprehensive review on dietary assessment methods in epidemiological research. Journal of Public Health and Nutrition, 3(2).
Yusefzadeh, H., Rashidi, A., & Rahimi, B. (2019). Economic burden of obesity: A systematic review. In Social Health and Behavior (Vol. 2, Issue 1). https://doi.org/10.4103/SHB.SHB_37_18
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Nina Maryana, Elma Nanda, Miftah Fadilah

This work is licensed under a Creative Commons Attribution 4.0 International License.













